The USA version ends with a simple 'End', but the Japanese Famicom version contains staff credits. The ending sequence allows the player to throw a giant kanji character ( 怒, Ikari:Anger) towards Murdock after returning to the base, which inexplicably turns Murdock into a frog. Later in the game, Rambo picks up an arsenal of weapons and fights enemy soldiers, but this happens close to the end of the game. In the Japanese version, the experience meter is replaced by an anger meter however, it functions exactly the same.

The game has similar gameplay to Zelda II: The Adventure of Link. Bosses include giant spiders and helicopters. Rambo then drops into the forest and fights spiders and other forest creatures. Players advance through the camp and talk to others, and when talking to Trautman again, he tells Rambo the mission. Players are given a choice, but cannot advance in the game unless 'yes' is chosen. The game starts off with Colonel Trautman asking Rambo whether or not he wants to leave the prison and start the mission. It is based on the film Rambo: First Blood Part II (1985). It was released on Decemin Japan, and May 1988 in North America. Rambo is a side-scrolling action-adventure video game produced by Pack-In-Video for the Nintendo Entertainment System (NES).

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